Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5648424 | 0.78 | MEN1 (0.33) | MEN1KMT2ACYP11B1CYP11B2RAB9A | |
| SCHEMBL18698526 | 0.74 | QDPR (0.51) | CREBBP | |
| SCHEMBL7819793 | 0.72 | GRIN2B (0.31) | — | |
| SCHEMBL31533760 | 0.70 | GAA (0.39) | MEN1KMT2A | |
| SCHEMBL6927527 | 0.70 | ALDH1A1 (0.54) | MEN1KMT2ACREBBPPDE3BPDE3A | |
| SCHEMBL6310104 | 0.70 | GAA (0.39) | MEN1KMT2A | |
| SCHEMBL12479372 | 0.70 | CREBBP (0.44) | CREBBP | |
| SCHEMBL11034392 | 0.69 | MEN1 (0.40) | MEN1KMT2ACYP11B1CYP11B2RAB9A | |
| SCHEMBL2544959 | 0.69 | ALDH1A1 (0.46) | — | |
| SCHEMBL410815 | 0.67 | HRH4 (0.46) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6593335-B1 | Disease than can be ameliorated with a potassium channel opener in a host mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of the compound of claim 1; said disease is epilepsy, Raynaud's | ABBOTT LABORATORIES | 2003-07-15 | — | — | US | disclosed |