Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30975319 | 0.81 | SLC6A4 (0.34) | GRIN2B | |
| SCHEMBL7090123 | 0.79 | KDM4E (0.42) | GAATSHR | |
| SCHEMBL25468145 | 0.79 | CHRNB2 (0.35) | GRIN2BHCRTR1HCRTR2GLAPOLB | |
| SCHEMBL7811713 | 0.76 | AKR1C3 (0.39) | — | |
| SCHEMBL22816076 | 0.74 | PDE10A (0.32) | BACE1 | |
| SCHEMBL21962283 | 0.73 | KDM1A (0.35) | BACE1GAA | |
| SCHEMBL7818101 | 0.73 | KIF11 (0.46) | — | |
| SCHEMBL7234652 | 0.72 | MEN1 (0.33) | — | |
| SCHEMBL12952676 | 0.72 | RAB9A (0.50) | POLB | |
| SCHEMBL9367414 | 0.72 | GAA (0.40) | GLAPOLBGAATSHRPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655996-B1 | SUBSTITUTED BENZYLAMINO NITROGEN CONTAINING NON-AROMATIC HETEROCYCLES | PFIZER (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-1114823-A2 | Substituted benzylamino nitrogen containing non-aromatic heterocycles | PFIZER INC. (US) | 2001-07-11 | — | — | EP | disclosed |
| US-5721255-A | Substituted benzylamino nitrogen containing non-aromatic heterocycles | PFIZER INC. (US) | 1998-02-24 | — | — | US | disclosed |