Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 5/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.39 |
| ▸ | HTR3B | O95264 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226412 | 0.86 | ULK1 (0.42) | USP30MMP12CHRNB2CHRNA4HDAC6 | |
| SCHEMBL7230682 | 0.84 | USP30 (0.36) | USP30HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7225737 | 0.81 | KDM4E (0.42) | USP30 | |
| SCHEMBL7223338 | 0.80 | CHRNA7 (0.57) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL375517 | 0.80 | CHRNA7 (0.57) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7235019 | 0.79 | CCNA2 (0.38) | CHRNB2CHRNA4HTR3EHTR3BHTR3A | |
| SCHEMBL7226905 | 0.79 | HPGD (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7230705 | 0.79 | HTR3E (0.39) | CHRNB2CHRNA4HTR3EHTR3BHTR3A | |
| SCHEMBL7225954 | 0.79 | CCNA2 (0.38) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7071274 | 0.77 | USP30 (0.53) | USP30CHRNB2CHRNA4HDAC6HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |