Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.58 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.58 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.54 |
| ▸ | HTR1B | P28222 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323457 | 0.87 | SIGMAR1 (0.62) | TSHRCARM1PRMT6PRMT8SIGMAR1 | |
| SCHEMBL615516 | 0.82 | TSHR (0.65) | TSHRCARM1PRMT6PRMT8SMN1; SMN2 | |
| SCHEMBL7055109 | 0.81 | CARM1 (0.75) | TSHRCARM1PRMT6PRMT8SMN1; SMN2 | |
| SCHEMBL9302526 | 0.80 | CARM1 (0.68) | TSHRCARM1PRMT6PRMT8SMN1; SMN2 | |
| SCHEMBL616042 | 0.79 | TSHR (0.62) | TSHRCARM1PRMT6PRMT8SMN1; SMN2 | |
| SCHEMBL13136911 | 0.79 | TSHR (0.61) | TSHRCARM1PRMT6PRMT8SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10598852 | 0.79 | CARM1 (0.61) | TSHRCARM1PRMT6PRMT8SMN1; SMN2 | |
| SCHEMBL17682060 | 0.79 | TSHR (0.81) | TSHRCARM1PRMT6PRMT8HTR1D | |
| SCHEMBL8702923 | 0.79 | TSHR (0.53) | TSHRCARM1PRMT6PRMT8SMN1; SMN2 | |
| SCHEMBL19715501 | 0.78 | TSHR (0.61) | TSHRCARM1PRMT6PRMT8SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234516-A1 | 1,6-Naphthyridine derivatives, process for their preparation and medicine containing them for the treatment of vascular diseases | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1987-09-02 | — | — | EP | claimed |
| US-6593335-B1 | Disease than can be ameliorated with a potassium channel opener in a host mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of the compound of claim 1; said disease is epilepsy, Raynaud's | ABBOTT LABORATORIES | 2003-07-15 | — | — | US | disclosed |
| EP-1194429-A1 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078768-A1 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-12-28 | — | — | WO | disclosed |
| US-4751228-A | 1,6-naphthyridine derivatives | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1988-06-14 | — | — | US | disclosed |
| EP-0234516-A1 | 1,6-Naphthyridine derivatives, process for their preparation and medicine containing them for the treatment of vascular diseases | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1987-09-02 | — | — | EP | disclosed |