Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MPI | P34949 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | USP8 | P40818 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7241965 | 0.86 | EPHX2 (0.56) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| SCHEMBL7242287 | 0.84 | MAPT (0.45) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| SCHEMBL7634838 | 0.78 | MAPT (0.46) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| SCHEMBL7234580 | 0.76 | EPHX2 (0.57) | ALDH1A1KDM4EMAPTEPHX2USP8 | |
| SCHEMBL7239552 | 0.76 | ALDH1A1 (0.46) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| SCHEMBL7243090 | 0.75 | EPHX2 (0.42) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| SCHEMBL7638011 | 0.75 | MAPT (0.45) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| SCHEMBL7234972 | 0.73 | L3MBTL1 (0.45) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| SCHEMBL7233236 | 0.69 | USP8 (0.48) | ALDH1A1KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL7243350 | 0.69 | ALDH1A1 (0.46) | ALDH1A1KDM4EKMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506747-B1 | Method of treating an inflammatory disease which comprises administering to a patient in need of such treatment-a N-(4-(5-Ethyl-3-pyridin-3-yl-pyrazol-1-yl)phenyl)pyridine-3-carboxamide; | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2003-01-14 | — | — | US | disclosed |