Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 4/20 | 0.38 |
| ▸ | BTK | Q06187 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7241783 | 0.90 | PTGS2 (0.37) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| SCHEMBL7234972 | 0.85 | L3MBTL1 (0.45) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| SCHEMBL7634838 | 0.82 | MAPT (0.46) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| SCHEMBL7241965 | 0.80 | EPHX2 (0.56) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| SCHEMBL7237050 | 0.78 | FYN (0.43) | ALDH1A1MAPTSMN1; SMN2TSHRHTT | |
| SCHEMBL7243590 | 0.76 | PTGS2 (0.39) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| SCHEMBL7235296 | 0.76 | ALDH1A1 (0.45) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| SCHEMBL7242287 | 0.74 | MAPT (0.45) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| SCHEMBL7244587 | 0.73 | VCP (0.37) | — | |
| SCHEMBL7638011 | 0.72 | MAPT (0.45) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6627647-B1 | Substituted 1-(4-aminophenyl)imidazoles and their use as anti-inflammatory agents | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2003-09-30 | — | — | US | claimed |
| WO-2001070703-A2 | SUBSTITUTED 1-(4-AMINOPHENYL)IMIDAZOLES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-09-27 | — | — | WO | claimed |