Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179175 | 0.84 | PROKR1 (0.53) | PROKR1GFERKDM4EPKMALDH1A1 | |
| SCHEMBL937205 | 0.84 | PROKR1 (0.63) | PROKR1GFERKDM4EPKMALDH1A1 | |
| SCHEMBL939096 | 0.84 | PROKR1 (0.63) | PROKR1GFERKDM4EALDH1A1HPGD | |
| SCHEMBL4059188 | 0.83 | POLB (0.59) | PROKR1GFERKDM4EALDH1A1HPGD | |
| SCHEMBL30667713 | 0.83 | PROKR1 (0.61) | PROKR1GFERALDH1A1HPGDMEN1 | |
| SCHEMBL1859158 | 0.83 | PROKR1 (0.61) | PROKR1GFERALDH1A1HPGDMEN1 | |
| SCHEMBL3763863 | 0.81 | PROKR1 (0.50) | PROKR1GFERKDM4EPKMALDH1A1 | |
| SCHEMBL3249195 | 0.80 | PKM (0.63) | PROKR1KDM4EPKMALDH1A1HPGD | |
| SCHEMBL7492026 | 0.80 | SIGMAR1 (0.54) | PROKR1GFERKDM4EHPGD | |
| SCHEMBL7496576 | 0.79 | SMN1; SMN2 (0.49) | PROKR1GFERKDM4EPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586423-B2 | 2-(Pyridin-2-ylamino)-thiazole-5-carbonitrile derivatives; angiogenesis inhibitors; antitumor and anticarcinogenic agents; atherosclerosis, macular degeneration, diabetic retinopathy | MERCK & CO., INC. | 2003-07-01 | — | — | US | disclosed |