Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 8/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 7/20 | 0.34 |
| ▸ | CACNA1S | Q13698 | 7/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7243873 | 0.85 | ADRA1A (0.39) | ADRA1AADORA3MEN1KMT2AATM | |
| SCHEMBL7242862 | 0.85 | ADRA1A (0.39) | ADRA1AADORA3MEN1KMT2AATM | |
| SCHEMBL7240694 | 0.85 | ADRA1A (0.41) | ADRA1AADORA3MEN1KMT2AATM | |
| SCHEMBL7244680 | 0.79 | ADORA3 (0.54) | ADRA1AADORA3MEN1KMT2ACACNA1D | |
| SCHEMBL7243692 | 0.78 | ADORA3 (0.42) | ADRA1AADORA3MEN1KMT2AATM | |
| SCHEMBL7245390 | 0.75 | ADORA3 (0.40) | ADRA1AADORA3MEN1KMT2AATM | |
| SCHEMBL7236794 | 0.75 | ADORA3 (0.43) | ADRA1AADORA3MEN1KMT2AATM | |
| SCHEMBL7244035 | 0.74 | ADRA1A (0.39) | ADRA1AADORA3ATML3MBTL1CACNA1D | |
| SCHEMBL7243776 | 0.72 | ADORA3 (0.52) | ADRA1AADORA3MEN1KMT2ACACNA1D | |
| SCHEMBL7238021 | 0.72 | ADORA3 (0.41) | ADRA1AADORA3MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608086-B2 | Selective adrenergic receptor alpha 1C antagonists without significant calcium channel activity; treating benign prostatic hyperplasia, intraocular pressure and inhibiting cholesterol synthesis | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-08-19 | — | — | US | disclosed |
| US-20020193599-A1 | Dihydropyridines and new uses thereof | SYNAPTIC PHARMACEUTICAL CORPORATION | 2002-12-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193599-A1 | Dihydropyridines and new uses thereof | BPHL, BCKDK, DHCR7 | ADRA1A 73/4885ADORA3 2012/4885MEN1 2239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.