SCHEMBL7238136

SCHEMBL7238136

CNC(=O)c1cccc(NC(=O)Cc2ccc(Cl)cc2)c1

nearest known ligand 0.66

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.66
MEN1 O00255 5/20 0.66
ALDH1A1 P00352 3/20 0.66
KDM4E B2RXH2 2/20 0.66
TP53 P04637 1/20 0.66
NLRP3 Q96P20 1/20 0.65
POLB P06746 2/20 0.60
HPGD P15428 1/20 0.60
LMNA P02545 2/20 0.58
KCNJ6 P48051 1/20 0.58
KCNJ5 P48544 1/20 0.58
KCNJ3 P48549 1/20 0.58
MAPT P10636 4/20 0.56
ANO1 Q5XXA6 2/20 0.54
KCNH2 Q12809 1/20 0.53
CNR1 P21554 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7237004 0.88 KDM4E (0.62) KMT2AMEN1ALDH1A1KDM4ETP53
SCHEMBL7239646 0.88 NLRP3 (0.67) KMT2AMEN1ALDH1A1KDM4ETP53
SCHEMBL7236516 0.88 NLRP3 (0.59) KMT2AMEN1ALDH1A1KDM4ETP53
SCHEMBL7246958 0.88 KMT2A (0.72) KMT2AMEN1ALDH1A1KDM4EPOLB
SCHEMBL7627434 0.87 ALDH1A1 (0.67) KMT2AMEN1ALDH1A1KDM4ENLRP3
SCHEMBL7238522 0.87 NLRP3 (0.65) KMT2AMEN1ALDH1A1KDM4ETP53
SCHEMBL7242115 0.85 NLRP3 (0.69) KMT2AMEN1ALDH1A1TP53NLRP3
SCHEMBL6577323 0.83 NLRP3 (0.67) KMT2AMEN1ALDH1A1KDM4ETP53
SCHEMBL7244275 0.83 GAA (0.69) KMT2AMEN1ALDH1A1KDM4ETP53
SCHEMBL7168527 0.82 L3MBTL1 (0.69) KMT2AMEN1ALDH1A1NLRP3HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030083523-A1 Amide derivatives MITSUBISHI CHEMICAL CORPORATION (JP) 2003-05-01 US claimed
EP-0887341-A1 Amide derivatives MITSUBISHI CHEMICAL CORPORATION (JP) 1998-12-30 EP claimed
US-20030083523-A1 Amide derivatives MITSUBISHI CHEMICAL CORPORATION (JP) 2003-05-01 US disclosed
US-6444849-B1 BACTERICIDES MITSUBISHI CHEMICAL CORPORATION (JP) 2002-09-03 US disclosed
EP-0887341-A1 Amide derivatives MITSUBISHI CHEMICAL CORPORATION (JP) 1998-12-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030083523-A1 Amide derivatives H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CBR3, CBR1 KMT2A 1956/4885MEN1 2901/4885ALDH1A1 1084/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.