Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233655 | 0.88 | L3MBTL1 (0.51) | OPRK1MAPTHSD11B1POLBL3MBTL1 | |
| SCHEMBL7234263 | 0.87 | KMT2A (0.49) | KDM4EALDH1A1HSD11B1CHIAHTT | |
| SCHEMBL2456713 | 0.85 | PRMT1 (0.53) | KDM4EOPRK1ALDH1A1HSD11B1PRMT1 | |
| SCHEMBL7235295 | 0.83 | MAPT (0.53) | KDM4EOPRK1MAPTALDH1A1HSD11B1 | |
| SCHEMBL7242145 | 0.82 | ALDH1A1 (0.50) | OPRK1ALDH1A1HSD11B1 | |
| SCHEMBL7242879 | 0.77 | CAPN1 (0.47) | MAPTHSD11B1CHIA | |
| SCHEMBL7235461 | 0.76 | CAPN1 (0.47) | HSD11B1CHIA | |
| SCHEMBL2221551 | 0.75 | MAPT (0.66) | KDM4EMAPTALDH1A1HSD11B1POLB | |
| SCHEMBL7242881 | 0.75 | ALDH1A1 (0.58) | KDM4EOPRK1MAPTALDH1A1HSD11B1 | |
| SCHEMBL7238619 | 0.75 | L3MBTL1 (0.54) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562827-B1 | For the treatment of diseases in which increased calpain activity occurs such as neurodegenerative diseases or neuronal damage are caused by ischemia, trauma or mass hemorrhages | ABBOTT LABORATORIES | 2003-05-13 | — | — | US | disclosed |