Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.44 |
| ▸ | HTR3B | O95264 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7239131 | 0.87 | KDM4E (0.48) | ALDH1A1HSD11B1KDM4ECHIAHTT | |
| SCHEMBL7238619 | 0.85 | L3MBTL1 (0.54) | KMT2AHSD17B10 | |
| SCHEMBL7235226 | 0.83 | HTR3E (0.61) | KMT2AALDH1A1HTR3EHTR3BHTR3A | |
| SCHEMBL7242879 | 0.82 | CAPN1 (0.47) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7235461 | 0.82 | CAPN1 (0.47) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7239796 | 0.81 | SIGMAR1 (0.54) | KMT2AALDH1A1HSD17B10 | |
| SCHEMBL7238307 | 0.79 | TSHR (0.48) | ALDH1A1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL2222747 | 0.78 | HTR3E (0.53) | KMT2AALDH1A1HTR3EHTR3BHTR3A | |
| SCHEMBL7235600 | 0.78 | ALDH1A1 (0.53) | KMT2AALDH1A1TSHR | |
| SCHEMBL15294735 | 0.78 | KMT2A (0.70) | KMT2AALDH1A1KDM4ETSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562827-B1 | For the treatment of diseases in which increased calpain activity occurs such as neurodegenerative diseases or neuronal damage are caused by ischemia, trauma or mass hemorrhages | ABBOTT LABORATORIES | 2003-05-13 | — | — | US | disclosed |