Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 8/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9132239 | 1.00 | NR1H2 (0.35) | NR1H2SRCCYP19A1SIGMAR1SMN1; SMN2 | |
| SCHEMBL9132721 | 0.90 | CYP19A1 (0.31) | CYP19A1SIGMAR1 | |
| SCHEMBL7805577 | 0.85 | ECE1 (0.33) | CYP19A1SIGMAR1 | |
| SCHEMBL7233657 | 0.85 | SIGMAR1 (0.33) | NR1H2CYP19A1SIGMAR1SMN1; SMN2 | |
| SCHEMBL9132237 | 0.82 | CYP19A1 (0.42) | NR1H2CYP19A1SMN1; SMN2 | |
| SCHEMBL9132827 | 0.80 | NPSR1 (0.43) | CYP19A1SIGMAR1 | |
| SCHEMBL15275774 | 0.78 | BTK (0.39) | NR1H2CYP19A1SMN1; SMN2 | |
| SCHEMBL13554888 | 0.78 | BTK (0.39) | NR1H2CYP19A1SMN1; SMN2 | |
| SCHEMBL7235416 | 0.77 | CYP19A1 (0.38) | CYP19A1 | |
| SCHEMBL8550129 | 0.76 | CYP19A1 (0.35) | CYP19A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6541491-B1 | Treating ras mediated diseases, especially cancer. | ZENECA LIMITED (GB) | 2003-04-01 | — | — | US | disclosed |
| US-6232338-B1 | 4-Mercaptopyrrolidine derivatives as farnesyl transferase inhibitors | ZENECA LIMITED (GB) | 2001-05-15 | — | — | US | disclosed |
| EP-0842151-A1 | 4-MERCAPTOPYRROLIDINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997006138-A1 | 4-MERCAPTOPYRROLIDINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1997-02-20 | — | — | WO | disclosed |