Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9795176 | 0.86 | ECE1 (0.38) | ECE1 | |
| SCHEMBL8832600 | 0.85 | ECE1 (0.32) | ECE1SIGMAR1 | |
| SCHEMBL9132239 | 0.85 | NR1H2 (0.35) | SIGMAR1CYP19A1 | |
| SCHEMBL7239236 | 0.85 | NR1H2 (0.35) | SIGMAR1CYP19A1 | |
| SCHEMBL8805757 | 0.84 | SIGMAR1 (0.33) | SIGMAR1CYP19A1 | |
| SCHEMBL8805750 | 0.84 | SIGMAR1 (0.33) | SIGMAR1CYP19A1 | |
| SCHEMBL9794941 | 0.83 | ECE1 (0.41) | ECE1 | |
| SCHEMBL5095470 | 0.82 | ATM (0.34) | SIGMAR1CYP19A1 | |
| SCHEMBL8786851 | 0.82 | ATM (0.34) | SIGMAR1CYP19A1 | |
| SCHEMBL5095282 | 0.82 | ATM (0.34) | SIGMAR1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932381-B2 | Reacting a 2-diaminosulfone, 5-mercaptpo, N- carboxyacrylate pyrrole with a phosphate substituted carbapenem in the presence of a secondary amine, and benzyl alcohol; deprotecting with a Pd catalyst; antibiotic | SHIONOGI & CO., LTD. (JP) | 2011-04-26 | — | — | US | disclosed |
| US-20080171864-A1 | Process for Producing Carbapenem Derivative and Intermediate Crystal Therefor | SHIONOGI & CO., LTD. (JP) | 2008-07-17 | — | — | US | disclosed |
| EP-0528678-B1 | A pyrrolidylthiocarbapenem derivative with antibacterial activity | SHIONOGI & CO (JP) | 2001-05-23 | — | — | EP | disclosed |
| US-6180622-B1 | ANTIMICROBIAL ACTIVITY AGAINST A WIDE RANGE OF BACTERIA INCLUDING GRAM-POSITIVE BACTERIA, GRAM-NEGATIVE BACTERIA, BETA-LACTAMASE-PRODUCING BACTERIA, RESISTANT PSEUDOMONAS AERUGINOSA,METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS AND | MEIJI SEIKA KAISHA, LTD. (JP) | 2001-01-30 | — | — | US | disclosed |
| EP-0887352-A1 | CARBAPENEM DERIVATIVES AND ANTIMICROBIALS | MEIJI SEIKA KAISHA LTD. (JP) | 1998-12-30 | — | — | EP | disclosed |
| US-5703243-A | Intermediates for pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1997-12-30 | — | — | US | disclosed |
| EP-0411664-B1 | 2-(2-Vinylpyrrolidinylthio)carbapenem derivatives | BANYU PHARMA CO LTD (JP) | 1995-01-18 | — | — | EP | disclosed |
| US-5317016-A | Pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-05-31 | — | — | US | disclosed |
| EP-0528678-A1 | A pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1993-02-24 | — | — | EP | disclosed |
| US-5095013-A | Antibiotics | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1992-03-10 | — | — | US | disclosed |
| EP-0411664-A2 | 2-(2-Vinylpyrrolidinylthio)carbapenem derivatives | Banyu Pharmaceutical Co., Ltd. (JP) | 1991-02-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171864-A1 | Process for Producing Carbapenem Derivative and Intermediate Crystal Therefor | SI, GSK3B, GSK3A | ECE1 3621/4885SIGMAR1 1955/4885CYP19A1 3043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.