Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7388573 | 0.92 | TDP1 (0.45) | MEN1KMT2AIDO1HRH3NPC1 | |
| SCHEMBL3886046 | 0.87 | CA1 (0.44) | MEN1KMT2AIDO1HRH3NPC1 | |
| SCHEMBL4884524 | 0.87 | LTA4H (0.58) | — | |
| SCHEMBL28130088 | 0.85 | IDO1 (0.61) | MEN1KMT2AIDO1HRH3DRD2 | |
| SCHEMBL198134 | 0.84 | TSHR (0.52) | MEN1KMT2AIDO1HRH3NPC1 | |
| SCHEMBL7429112 | 0.83 | IDO1 (0.55) | MEN1KMT2AIDO1HRH3DRD2 | |
| SCHEMBL1001167 | 0.81 | TSHR (0.58) | IDO1HRH3TDP1L3MBTL1 | |
| SCHEMBL6895507 | 0.81 | LTA4H (0.55) | TDP1L3MBTL1 | |
| SCHEMBL10500468 | 0.80 | CA1 (0.45) | IDO1NPC1RAB9AHTR2ACA1 | |
| SCHEMBL4889966 | 0.80 | ESR1 (0.48) | KMT2AHTR2CSIGMAR1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1129599-C | Substituted benzothiazine/oxazine-2-amine derivatives, co-preparation method and application thereof | PF MEDICAMENT (FR) | 2003-12-03 | — | — | CN | disclosed |
| US-6531469-B1 | Treatment of myocardial ischemia, chronic stable angina, unstable angina and prinzmetal's angina attacks, silent cardiac ischemia, reinfarction, reocclusion and restenosis | PIERRE FABRE MEDICAMENT (FR) | 2003-03-11 | — | — | US | disclosed |
| EP-1144408-B1 | SUBSTITUTED 1-(PIERIDIN-4-YL)-3-(ARYL) ISOTHIOUREAS THEIR PREPARATION AND THERAPEUTIC APPLICATION | PF MEDICAMENT (FR) | 2002-09-25 | — | — | EP | disclosed |
| CN-1344267-A | Substituted 1- (piperidin-4-yl) -3- (aryl) isothioureas, their preparation and their therapeutic use | PF MEDICAMENT (FR) | 2002-04-10 | — | — | CN | disclosed |
| EP-1144408-A1 | SUBSTITUTED 1-(PIERIDIN-4-YL)-3-(ARYL) ISOTHIOUREAS THEIR PREPARATION AND THERAPEUTIC APPLICATION | PIERRE FABRE MEDICAMENT (FR) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000043391-A1 | SUBSTITUTED 1-(PIERIDIN-4-YL)-3-(ARYL) ISOTHIOUREAS THEIR PREPARATION AND THERAPEUTIC APPLICATION | PIERRE FABRE MEDICAMENT (FR) | 2000-07-27 | — | — | WO | disclosed |