Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29173176 | 0.92 | L3MBTL1 (0.60) | L3MBTL1MAPK1ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL1313733 | 0.90 | L3MBTL1 (0.74) | L3MBTL1MAPK1ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6472886 | 0.88 | L3MBTL1 (0.59) | L3MBTL1MAPK1ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6043936 | 0.87 | L3MBTL1 (0.58) | L3MBTL1MAPK1ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6444665 | 0.86 | TDP1 (0.61) | L3MBTL1MAPK1ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL311599 | 0.86 | L3MBTL1 (0.59) | L3MBTL1MAPK1ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6583837 | 0.84 | L3MBTL1 (0.55) | L3MBTL1MAPK1ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL7396626 | 0.84 | ALDH1A1 (0.53) | L3MBTL1MAPK1ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL27424667 | 0.82 | L3MBTL1 (0.56) | L3MBTL1MAPK1ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL1671161 | 0.82 | KDM4E (0.52) | L3MBTL1MAPK1ALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670366-B1 | Cyclic guanosine 3',5'-monophosphate phosphodiesterase inhibitors; impotence; pyrazolo(4,3-d)pyrimidin-7-ones | PFIZER INC | 2003-12-30 | — | — | US | disclosed |
| EP-0995750-A1 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. (US) | 2000-04-26 | — | — | EP | disclosed |