Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LSS | P48449 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7238619 | 0.96 | L3MBTL1 (0.54) | SIGMAR1KMT2AL3MBTL1HSD17B10FAAH | |
| SCHEMBL7235600 | 0.88 | ALDH1A1 (0.53) | KMT2AFAAHALDH1A1 | |
| SCHEMBL7235295 | 0.87 | MAPT (0.53) | SIGMAR1KMT2AL3MBTL1CFTRDRD2 | |
| SCHEMBL7235226 | 0.87 | HTR3E (0.61) | SIGMAR1KMT2AHSD17B10DRD4MAPT | |
| SCHEMBL2222971 | 0.86 | MAPT (0.59) | SIGMAR1KMT2AL3MBTL1HSD17B10FAAH | |
| SCHEMBL7233655 | 0.84 | L3MBTL1 (0.51) | SIGMAR1KMT2AL3MBTL1HRH3CFTR | |
| SCHEMBL2222713 | 0.84 | MAPT (0.56) | SIGMAR1KMT2AL3MBTL1HSD17B10CFTR | |
| SCHEMBL7238934 | 0.83 | L3MBTL1 (0.50) | SIGMAR1KMT2AL3MBTL1HSD17B10FAAH | |
| SCHEMBL2228942 | 0.82 | MAPT (0.55) | KMT2AL3MBTL1HSD17B10HRH3CFTR | |
| SCHEMBL2223585 | 0.82 | MAPT (0.55) | KMT2AL3MBTL1HSD17B10HRH3CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562827-B1 | For the treatment of diseases in which increased calpain activity occurs such as neurodegenerative diseases or neuronal damage are caused by ischemia, trauma or mass hemorrhages | ABBOTT LABORATORIES | 2003-05-13 | — | — | US | disclosed |