Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 7/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7240547 | 1.00 | HRH2 (0.43) | HRH2HRH4HRH3DRD2DRD3 | |
| SCHEMBL7230300 | 0.91 | ACACB (0.40) | HRH2GAAMAPTTTKMAPK8 | |
| SCHEMBL7228914 | 0.90 | SIGMAR1 (0.41) | HRH2HRH4HRH3DRD2DRD3 | |
| SCHEMBL7229573 | 0.81 | CCR1 (0.40) | MAPTACACBACACALMNATP53 | |
| Hydrochloric Acid SCHEMBL7230311 | 0.79 | ADRA2A (0.50) | GAAMAPTTTKMAPK8TP53 | |
| SCHEMBL7847281 | 0.77 | KMT2A (0.41) | MAPTTTKMAPK8ACACBACACA | |
| SCHEMBL7229865 | 0.77 | CNR1 (0.43) | ACACBACACA | |
| SCHEMBL7847265 | 0.73 | KDM4E (0.40) | MAPTLMNANPC1TP53RAB9A | |
| SCHEMBL7229054 | 0.73 | MAPT (0.47) | MAPTACACBACACALMNAHTT | |
| SCHEMBL7847263 | 0.73 | KDM4E (0.40) | MAPTLMNANPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521643-B1 | Prevention and/or treatment of nitric oxide synthasey medi-ated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, diabetes, ulcerative colitis, cerebral infarction, osteoarthritis | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-02-18 | — | — | US | disclosed |