Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7242245 | 0.91 | MAPT (0.46) | MAPTPOLBTP53PKMALDH1A1 | |
| SCHEMBL7245777 | 0.86 | MAPT (0.52) | MAPTPOLBTP53PKMALDH1A1 | |
| SCHEMBL7242634 | 0.83 | POLB (0.45) | MAPTPOLBTP53PKMALDH1A1 | |
| SCHEMBL7241756 | 0.83 | MAPT (0.51) | MAPTPOLBTP53PKMALDH1A1 | |
| SCHEMBL7243828 | 0.82 | POLB (0.47) | MAPTPOLBTP53PKMALDH1A1 | |
| SCHEMBL7242624 | 0.81 | MAPT (0.65) | MAPTPOLBTP53PKMALDH1A1 | |
| SCHEMBL7242372 | 0.81 | MAPT (0.46) | MAPTPOLBTP53PKMALDH1A1 | |
| SCHEMBL2658901 | 0.80 | POLB (0.45) | MAPTPOLBTP53PKMALDH1A1 | |
| SCHEMBL7241685 | 0.80 | MAPT (0.43) | MAPTPOLBTP53PKMALDH1A1 | |
| SCHEMBL7241998 | 0.79 | KMT2A (0.53) | MAPTPOLBTP53ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030045532-A1 | Triazolo-pyrimidine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-03-06 | — | — | US | claimed |
| US-20030045532-A1 | Triazolo-pyrimidine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045532-A1 | Triazolo-pyrimidine derivatives as ligands for gaba receptors | GABRA3, GABRA2, GABRA4 | MAPT 1447/4885POLB 3552/4885TP53 4589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.