Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7241182 | 0.84 | HTR2A (0.41) | MEN1KMT2AHTR2AHTR2CALDH1A1 | |
| SCHEMBL7666030 | 0.79 | C1S (0.43) | MEN1KMT2APOLBPKMHTR2A | |
| SCHEMBL7241945 | 0.77 | HTR2A (0.35) | MAPTHTR2AHTR2C | |
| SCHEMBL6927428 | 0.72 | C1S (0.54) | — | |
| SCHEMBL7247948 | 0.70 | ALDH1A1 (0.51) | MAPTMCOLN3MEN1KMT2APOLB | |
| SCHEMBL7665285 | 0.68 | ALDH1A1 (0.45) | C5AR1MEN1KMT2AKDM4ECA12 | |
| SCHEMBL11651081 | 0.65 | C5AR1 (0.59) | C5AR1MAPTMCOLN3AGERKMT2A | |
| SCHEMBL6990099 | 0.64 | MAPT (0.61) | C5AR1MAPTMCOLN3AGERATM | |
| SCHEMBL10956151 | 0.63 | CA12 (0.70) | C5AR1MAPTMCOLN3KMT2ACA12 | |
| SCHEMBL2367814 | 0.62 | CYP3A4 (0.48) | C5AR1MAPTMCOLN3AGERATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562840-B1 | Non-peptidic inhibitors of proteolytic enzymes such as urokinase | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-05-13 | — | — | US | disclosed |