Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 4/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 2/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7243748 | 0.82 | CETP (0.36) | CETPP2RX1MAPTCACNA1GCACNA1B | |
| SCHEMBL6676867 | 0.80 | CETP (0.40) | CETPMAPTCACNA1GCACNA1BCACNA1C | |
| SCHEMBL6677408 | 0.78 | CETP (0.42) | CETPP2RX1CACNA1GCACNA1BCACNA1C | |
| SCHEMBL6674825 | 0.78 | P2RX1 (0.39) | P2RX1MAPTTMPRSS4LMNAMEN1 | |
| Hydrochloric Acid SCHEMBL6681155 | 0.77 | P2RX1 (0.38) | P2RX1MAPTTMPRSS4LMNAMEN1 | |
| SCHEMBL7240779 | 0.75 | NR1H4 (0.35) | ALDH1A1LMNA | |
| SCHEMBL6678261 | 0.73 | CETP (0.43) | CETPCACNA1GCACNA1BCACNA1CTACR1 | |
| SCHEMBL6681975 | 0.71 | AKT1 (0.44) | — | |
| SCHEMBL6690431 | 0.68 | BACE1 (0.41) | MAPTMEN1KMT2A | |
| SCHEMBL10384367 | 0.68 | MAPT (0.52) | MAPTALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |