Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 3/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6684630 | 0.86 | GPR35 (0.37) | SIGMAR1P2RX1MAPTTMPRSS4ALDH1A1 | |
| SCHEMBL6676867 | 0.82 | CETP (0.40) | CETPCACNA1GCACNA1BCACNA1CGRM2 | |
| SCHEMBL7243745 | 0.82 | CETP (0.38) | CETPCACNA1GCACNA1BCACNA1CP2RX1 | |
| SCHEMBL6674828 | 0.79 | SIGMAR1 (0.39) | SIGMAR1P2RX1RAF1BRAFMAPT | |
| Hydrochloric Acid SCHEMBL6681157 | 0.78 | SIGMAR1 (0.40) | SIGMAR1P2RX1RAF1BRAFMAPT | |
| SCHEMBL6677408 | 0.77 | CETP (0.42) | CETPCACNA1GCACNA1BCACNA1CP2RX1 | |
| SCHEMBL7240782 | 0.75 | MAPT (0.32) | GRM2MAPTALDH1A1 | |
| SCHEMBL6678261 | 0.74 | CETP (0.43) | CETPCACNA1GCACNA1BCACNA1CGRM2 | |
| SCHEMBL6681977 | 0.71 | AKT1 (0.43) | SIGMAR1 | |
| SCHEMBL6690435 | 0.68 | NOS3 (0.53) | SIGMAR1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |