Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F9 | P00740 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | GPR132 | Q9UNW8 | 7/20 | 0.41 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.41 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | KIF20A | O95235 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8023719 | 0.79 | F9 (0.48) | F9F10MAPK1GPR132CMKLR2 | |
| SCHEMBL8024562 | 0.75 | MMP13 (0.46) | F9F10MAOADYRK1A | |
| SCHEMBL8021621 | 0.69 | HPGD (0.48) | F9F10GPR132FGFR4EDNRA | |
| SCHEMBL3156910 | 0.68 | ALOX5 (0.58) | EDNRAMAOAALOX5 | |
| SCHEMBL7311175 | 0.68 | MAPK1 (0.65) | MAPK1GPR132CMKLR2CMKLR1IKBKB | |
| SCHEMBL28048524 | 0.68 | MAPK1 (0.64) | F9F10MAPK1GPR132MAOA | |
| SCHEMBL28244529 | 0.67 | ALOX5 (0.67) | F9F10MAPK1MAOADYRK1A | |
| SCHEMBL22964344 | 0.67 | MAPK1 (0.58) | F9F10MAPK1GPR132CMKLR2 | |
| SCHEMBL8024886 | 0.67 | MMP13 (0.48) | F9F10EDNRAMAOADYRK1A | |
| SCHEMBL28011530 | 0.67 | MAPK1 (0.64) | F9F10MAPK1GPR132CMKLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6555555-B1 | Inhibitors of interleukin-6 and/or interleukin-12; for example 4,5-dimethyl-1,1-dioxidebenzo(b)thiophene; treating various inflammatory diseases, autoimmune diseases, cancer, osteoporosis | ONO PHARMACEUTICAL CO., LTD. (JP) | 2003-04-29 | — | — | US | disclosed |