Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7628658 | 0.88 | ALDH1A1 (0.40) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL7235703 | 0.86 | ABCC9 (0.47) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL7629532 | 0.85 | ABCC9 (0.43) | GPR174ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7243050 | 0.85 | ABCC9 (0.45) | GPR174ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7239802 | 0.85 | ABCC9 (0.45) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL7626510 | 0.85 | ABCC9 (0.40) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL7626088 | 0.84 | MAPT (0.40) | ABCC9ABCC8KCNJ11KCNJ8GSK3A | |
| SCHEMBL7242435 | 0.83 | ABCC9 (0.47) | ABCC9ABCC8KCNJ11KCNJ8GSK3A | |
| SCHEMBL7234673 | 0.83 | ABCC9 (0.39) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL7235270 | 0.82 | ABCC9 (0.34) | ABCC9ABCC8KCNJ11KCNJ8GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6593335-B1 | Disease than can be ameliorated with a potassium channel opener in a host mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of the compound of claim 1; said disease is epilepsy, Raynaud's | ABBOTT LABORATORIES | 2003-07-15 | — | — | US | disclosed |