SCHEMBL724512

SCHEMBL724512

NC(=O)c1cc2c(nc1O)CCN(S(=O)(=O)c1ccc(C(F)(F)F)cc1)C2

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 1/20 0.51
NAMPT P43490 1/20 0.45
AKR1C3 P42330 3/20 0.42
PPARG P37231 1/20 0.41
PPARD Q03181 1/20 0.41
PPARA Q07869 1/20 0.41
HDAC1 Q13547 1/20 0.41
STS P08842 1/20 0.40
EPHX2 P34913 2/20 0.39
ALDH1A1 P00352 1/20 0.39
GAA P10253 3/20 0.39
KDM4E B2RXH2 1/20 0.39
EGLN1 Q9GZT9 1/20 0.38
JAK2 O60674 1/20 0.38
JAK1 P23458 1/20 0.38
ESR2 Q92731 1/20 0.38
ATM Q13315 1/20 0.38
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15048461 0.74 HDAC6 (0.65) HDAC6NAMPTAKR1C3PPARGPPARD
SCHEMBL720084 0.73 HDAC6 (0.71) HDAC6NAMPTAKR1C3PPARGPPARD
SCHEMBL4987925 0.71 HDAC6 (0.44) HDAC6NAMPTAKR1C3HDAC1EPHX2
SCHEMBL3282023 0.70 HDAC6 (0.71) HDAC6AKR1C3PPARGPPARDPPARA
SCHEMBL3637211 0.68 ALDH1A1 (0.55) HDAC6NAMPTEPHX2ALDH1A1GAA
SCHEMBL20046992 0.68 HDAC6 (0.69) HDAC6NAMPTAKR1C3PPARGPPARD
SCHEMBL4982876 0.67 HDAC6 (0.40) HDAC6NAMPTAKR1C3EPHX2ALDH1A1
SCHEMBL1264443 0.67 HDAC6 (1.00) HDAC6NAMPTAKR1C3PPARGPPARD
SCHEMBL25073166 0.67 MEN1 (0.47) AKR1C3PPARGPPARDPPARAALDH1A1
SCHEMBL30278512 0.67 MEN1 (0.47) AKR1C3PPARGPPARDPPARAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012027564-A1 SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF MILLENNIUM PHARMACEUTICALS, INC. (US) 2012-03-01 WO disclosed