Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12655864 | 0.90 | KMT2A (0.63) | ALDH1A1HDAC6KMT2AMEN1GAA | |
| SCHEMBL8219715 | 0.79 | ALDH1A1 (0.60) | ALDH1A1HDAC6KMT2AMEN1GAA | |
| SCHEMBL265611 | 0.79 | PKM (0.61) | ALDH1A1KMT2AMEN1GAALMNA | |
| SCHEMBL6559970 | 0.79 | KMT2A (0.56) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL15009887 | 0.78 | ALDH1A1 (0.77) | ALDH1A1KMT2AMEN1GAAEPHX2 | |
| SCHEMBL28254937 | 0.77 | ALDH1A1 (0.74) | ALDH1A1KMT2AMEN1GAAEPHX2 | |
| SCHEMBL693876 | 0.76 | HDAC6 (0.56) | ALDH1A1HDAC6KMT2AMEN1GAA | |
| SCHEMBL20046992 | 0.76 | HDAC6 (0.69) | ALDH1A1HDAC6KMT2AMEN1GAA | |
| SCHEMBL2299332 | 0.75 | KMT2A (0.51) | ALDH1A1KMT2AMEN1GAAEPHX2 | |
| SCHEMBL24295449 | 0.74 | EPHX2 (0.75) | ALDH1A1KMT2AMEN1GAAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152713-A1 | PYRAZOLOPYRROLIDINES AS INHIBITORS OF GAMMA SECRETASE | Elan Pharmaceuticals Inc. (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008147800-A1 | PYRAZOLOPYRROLIDINES AS INHIBITORS OF GAMMA SECRETASE | ELAN PHARMACEUTICALS, INC. (US) | 2008-12-04 | — | — | WO | disclosed |