Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.60 |
| ▸ | GRM8 | O00222 | 3/20 | 0.54 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.54 |
| ▸ | GRM6 | O15303 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31481066 | 0.86 | ALDH1A1 (0.56) | ALDH1A1GRM8GRM4GRM6CYP3A4 | |
| SCHEMBL3949842 | 0.86 | ALDH1A1 (0.56) | ALDH1A1GRM8GRM4GRM6CYP3A4 | |
| SCHEMBL7976515 | 0.84 | ALDH1A1 (0.55) | ALDH1A1GRM8GRM4GRM6CYP3A4 | |
| SCHEMBL7246635 | 0.84 | ALDH1A1 (0.55) | ALDH1A1GRM8GRM4GRM6CYP3A4 | |
| SCHEMBL7965004 | 0.83 | GRM8 (0.48) | ALDH1A1GRM8GRM4GRM6KMT2A | |
| SCHEMBL29192875 | 0.82 | GRM8 (0.52) | ALDH1A1GRM8GRM4GRM6CYP3A4 | |
| SCHEMBL31347515 | 0.80 | ALDH1A1 (0.51) | ALDH1A1GRM8GRM4GRM6CYP3A4 | |
| SCHEMBL19423129 | 0.80 | ALDH1A1 (0.53) | ALDH1A1GRM8GRM4GRM6CYP3A4 | |
| SCHEMBL187420 | 0.80 | ACHE (0.55) | ALDH1A1CYP3A4TSHRCYP2C19KMT2A | |
| SCHEMBL187421 | 0.80 | ACHE (0.55) | ALDH1A1CYP3A4TSHRCYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630496-B1 | Antiinflammatory agents inhibit phospholipase 2, affecting both protaglandin and leukotriene production; indoles substituted in 2 position by 2,4-dioxo-thiazol-3-yl methylidene | GENETICS INSTITUTE LLC | 2003-10-07 | — | — | US | disclosed |