Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.55 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.53 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | GPR183 | P32249 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7245709 | 1.00 | L3MBTL1 (0.70) | L3MBTL1NPC1MAPTALDH1A1MEN1 | |
| SCHEMBL31228779 | 0.84 | NPC1 (0.72) | L3MBTL1NPC1TRPM8LTB4RLTB4R2 | |
| SCHEMBL28501196 | 0.84 | NPC1 (0.72) | L3MBTL1NPC1MAPTALDH1A1POLB | |
| SCHEMBL31228704 | 0.84 | NPC1 (0.72) | L3MBTL1NPC1TRPM8LTB4RLTB4R2 | |
| SCHEMBL28378955 | 0.84 | ALDH1A1 (0.54) | L3MBTL1NPC1MAPTALDH1A1MEN1 | |
| SCHEMBL28514351 | 0.83 | NPC1 (0.70) | L3MBTL1NPC1MAPTMEN1KMT2A | |
| SCHEMBL28887174 | 0.83 | NPC1 (0.70) | L3MBTL1NPC1TRPM8LTB4RLTB4R2 | |
| N,N-Diethylcinnamamide SCHEMBL23550023 | 0.82 | NPC1 (1.00) | L3MBTL1NPC1MAPTALDH1A1RECQL | |
| N,N-Diethylcinnamamide SCHEMBL4956226 | 0.82 | NPC1 (1.00) | L3MBTL1NPC1MAPTALDH1A1RECQL | |
| N,N-Diethylcinnamamide SCHEMBL4956221 | 0.82 | NPC1 (1.00) | L3MBTL1NPC1MAPTALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030073671-A1 | Non-steroidal ligands for the estrogen receptor | WILLSON TIMOTHY MARK (US) | 2003-04-17 | — | — | US | disclosed |
| US-20010053774-A1 | Non-steroidal ligands for the estrogen receptor | GLAXO WELLCOME INC.. | 2001-12-20 | — | — | US | disclosed |
| US-6207716-B1 | FOR PROPHYLAXIS AND THERAPY OF OSTEOPOROSIS, ARTHRITIS, BREAST CANCER, CARDIOVASCULAR DISEASE | GLAXO WELLCOME INC. | 2001-03-27 | — | — | US | disclosed |
| US-5877219-A | Non-steroidal ligands for the estrogen receptor | GLAXO WELLCOMEINC. (US) | 1999-03-02 | — | — | US | disclosed |
| WO-1999007668-A1 | NON-STEROIDAL LIGANDS FOR THE ESTROGEN RECEPTOR | GLAXO WELLCOME INC. (US) | 1999-02-18 | — | — | WO | disclosed |
| US-5681835-A | USEFUL FOR TREATING OSTEOPOROSIS | GLAXO WELLCOME INC. (US) | 1997-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010053774-A1 | Non-steroidal ligands for the estrogen receptor | ESRRB, ESR2, ESRRA | L3MBTL1 4303/4885NPC1 2296/4885MAPT 4729/4885 |
| US-20030073671-A1 | Non-steroidal ligands for the estrogen receptor | ESRRB, ESR2, ESRRA | L3MBTL1 4303/4885NPC1 2296/4885MAPT 4729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.