Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8385275 | 0.85 | F10 (0.51) | EDNRBEDNRANOD2NOD1KDM4E | |
| SCHEMBL7468828 | 0.85 | EDNRB (0.47) | EDNRBEDNRANOD2NOD1MAPT | |
| SCHEMBL7247001 | 0.84 | MAPT (0.49) | NOD2NOD1KDM4EMAPTMAPK1 | |
| SCHEMBL7493053 | 0.83 | NOD2 (0.45) | NOD2NOD1KDM4EMAPTMAPK1 | |
| SCHEMBL8387936 | 0.82 | MAPT (0.47) | EDNRBEDNRANOD2NOD1MAPT | |
| SCHEMBL7461983 | 0.82 | MAOB (0.46) | EDNRBEDNRANOD2NOD1MAPT | |
| SCHEMBL7470558 | 0.82 | NOD2 (0.40) | NOD2NOD1KDM4EMAPTMAPK1 | |
| SCHEMBL7490635 | 0.80 | CCR2 (0.48) | NOD2NOD1KDM4EMAPTMAPK1 | |
| SCHEMBL7244666 | 0.79 | MAPT (0.39) | EDNRBEDNRANOD2NOD1KDM4E | |
| SCHEMBL7534493 | 0.79 | F10 (0.41) | EDNRBEDNRANOD2NOD1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670388-B1 | Fatty acid synthase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-12-30 | — | — | US | disclosed |
| WO-2002000620-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-03 | — | — | WO | disclosed |