Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7247001 | 0.86 | MAPT (0.49) | CCR2NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL7493053 | 0.85 | NOD2 (0.45) | CCR2NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL6300699 | 0.80 | CCR2 (0.74) | CCR2NOD2NOD1MAPTKDM4E | |
| SCHEMBL7246776 | 0.80 | EDNRB (0.43) | CCR2NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL17060318 | 0.80 | NOD2 (0.60) | CCR2NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL7470558 | 0.79 | NOD2 (0.40) | CCR2NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL8385275 | 0.79 | F10 (0.51) | NOD2NOD1MAPTALDH1A1KDM4E | |
| SCHEMBL7496568 | 0.79 | MAPT (0.44) | CCR2NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL4196083 | 0.79 | NOD2 (0.54) | CCR2NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL7468828 | 0.78 | EDNRB (0.47) | CCR2NOD2NOD1MAPTF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242075-A4 | INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2002-12-04 | — | — | EP | disclosed |
| EP-1242075-A2 | INDOLE COMPOUNDS | SmithKline Beecham Corporation (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001030752-A2 | INDOLE COMPOUNDS FOR TREATING BACTERIAL INFECTIONS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-03 | — | — | WO | disclosed |