Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.43 |
| ▸ | TUBB | P07437 | 4/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.43 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL723538 | 0.89 | TUBB4A (0.46) | PDE4CTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL723093 | 0.85 | PDE4C (0.55) | PDE4CCYP1A1CYP1A2CYP1B1PTGES | |
| SCHEMBL16638610 | 0.84 | PDE4C (0.47) | PDE4CCYP1A1CYP1A2CYP1B1PTGES | |
| SCHEMBL722937 | 0.83 | FYN (0.48) | ADORA2APDE4CTUBB4ATUBBTUBA3C | |
| SCHEMBL722839 | 0.83 | PDE4C (0.51) | PDE4CTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL15216687 | 0.83 | PDE4C (0.44) | PDE4CCYP1A1CYP1A2CYP1B1PTGES | |
| SCHEMBL724796 | 0.82 | PDE4C (0.43) | PDE4CCYP1A1CYP1A2CYP1B1PTGES | |
| SCHEMBL722753 | 0.82 | NEK2 (0.47) | PDE4CTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL15210488 | 0.81 | PDE4C (0.45) | PDE4CTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL722239 | 0.81 | TERT (0.47) | ADORA2APDE4CTUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | claimed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | claimed |
| US-20130225569-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-08-29 | — | — | US | claimed |
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | disclosed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-20130225569-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-08-29 | — | — | US | disclosed |
| EP-2609100-A2 | FUROPYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225569-A1 | FUROPYRIDINE DERIVATIVES | SYK, FCGRT, SSB | PDE7A 2568/4885PDE3A 1175/4885ADORA3 2845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.