Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11706244 | 0.78 | SLC2A1 (0.46) | MAPTKMT2ASMYD3MEN1CA12 | |
| SCHEMBL2969266 | 0.77 | CA12 (0.53) | MAPTSMN1; SMN2L3MBTL1KMT2APOLB | |
| SCHEMBL13373455 | 0.77 | CDK8 (0.49) | BRD4MAPTSMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL1255885 | 0.75 | MEN1 (0.56) | MAPTL3MBTL1KMT2APOLBMEN1 | |
| SCHEMBL8334023 | 0.74 | L3MBTL1 (0.54) | MAPTSMN1; SMN2L3MBTL1KMT2APOLB | |
| SCHEMBL6163681 | 0.74 | MEN1 (0.44) | BRD4MAPTSMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL2291968 | 0.74 | KMT2A (0.41) | L3MBTL1KMT2ASMYD3MEN1ALDH1A1 | |
| SCHEMBL205408 | 0.73 | CA1 (0.48) | ATMMAPTSMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL13729839 | 0.73 | HDAC8 (0.47) | SMN1; SMN2SMYD3HPGDHTTCA12 | |
| SCHEMBL31701218 | 0.73 | MAPT (0.46) | BRD4BAZ2BBAZ2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6632946-B2 | Biological activity inhibiting topoisomerase I and/or topoisomerase II; antitumor agents, viricides | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2003-10-14 | — | — | US | disclosed |
| US-6436951-B1 | 3-HYDROXY-3-(4-OXO-4,6-DIHYDROINDOLIZINO (1,2-B) QUINOLINE-2-YL) PENTANOIC ACID, INHIBITING TOPOISOMERASE I AND/OR II; ANTITUMOR, PARASITICIDE; REACTING A PYRIDINONE WITH A QUINOLINE, CYCLIZATION, EPOXIDATION | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-08-20 | — | — | US | disclosed |
| EP-1042323-B1 | NOVEL CAMPTOTHECIN TETRACYCLIC ANALOGUES, PREPARATION, METHODS, APPLICATIONS AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SOD CONSEILS RECH APPLIC (FR) | 2002-04-10 | — | — | EP | disclosed |
| US-20010000521-A1 | New tetracyclic analogues of camptothecins, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them | IPSEN PHARMA S.A.S. (FR) | 2001-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010000521-A1 | New tetracyclic analogues of camptothecins, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them | TOP2A, TOP1, TOP2B | ATM 2278/4885BRD4 3366/4885BAZ2B 3306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.