Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7248171 | 0.89 | LMNA (0.34) | TSHRLMNAALDH1A1DDB1CRBN | |
| SCHEMBL7130434 | 0.88 | DDB1 (0.41) | TSHRLMNAALDH1A1DDB1CRBN | |
| SCHEMBL7130438 | 0.76 | DDB1 (0.42) | TSHRLMNAALDH1A1DDB1CRBN | |
| SCHEMBL7134639 | 0.73 | USP2 (0.46) | LMNAALDH1A1GAA | |
| SCHEMBL7127902 | 0.73 | KDM4E (0.46) | LMNAALDH1A1KMT2A | |
| SCHEMBL29418139 | 0.71 | HTR7 (0.47) | TSHRLMNAALDH1A1KMT2A | |
| SCHEMBL2062838 | 0.69 | SCN9A (0.39) | TSHRLMNADDB1CRBNKMT2A | |
| SCHEMBL4498456 | 0.69 | L3MBTL1 (0.48) | TSHRLMNAALDH1A1KMT2AGAA | |
| SCHEMBL29418182 | 0.69 | KDM4E (0.55) | LMNAALDH1A1KMT2AGAA | |
| SCHEMBL16713302 | 0.67 | CYP1A2 (0.50) | TSHRALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6555555-B1 | Inhibitors of interleukin-6 and/or interleukin-12; for example 4,5-dimethyl-1,1-dioxidebenzo(b)thiophene; treating various inflammatory diseases, autoimmune diseases, cancer, osteoporosis | ONO PHARMACEUTICAL CO., LTD. (JP) | 2003-04-29 | — | — | US | disclosed |