Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | PROC | P04070 | 1/20 | 0.37 |
| ▸ | HPN | P05981 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7250212 | 0.87 | F2 (0.45) | HTR2CF2RAB9AHDAC1POLB | |
| SCHEMBL7253523 | 0.86 | F2 (0.47) | HTR2CF2RAB9AHDAC1HDAC8 | |
| SCHEMBL7248203 | 0.85 | F2 (0.42) | HTR2CF2RAB9AHDAC1HDAC8 | |
| SCHEMBL7249842 | 0.85 | F2 (0.43) | HTR2CF2RAB9AHDAC1HDAC8 | |
| SCHEMBL7249812 | 0.84 | PPARG (0.42) | HTR2CF2HDAC1HDAC8HDAC6 | |
| SCHEMBL7252575 | 0.83 | THRB (0.44) | HTR2CF2HDAC1HDAC8HDAC6 | |
| SCHEMBL7243857 | 0.83 | F2 (0.54) | F2RAB9AHDAC1HDAC8MEN1 | |
| SCHEMBL7249727 | 0.82 | F2 (0.41) | HTR2CF2RAB9AHDAC1HDAC8 | |
| SCHEMBL7256417 | 0.82 | F2 (0.43) | HTR2CF2HDAC1POLBHDAC8 | |
| SCHEMBL7250891 | 0.81 | L3MBTL1 (0.42) | HTR2CF2RAB9AHDAC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |