Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 9/20 | 0.79 |
| ▸ | PDE4A | P27815 | 5/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.66 |
| ▸ | HPGD | P15428 | 4/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | HK1 | P19367 | 1/20 | 0.62 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7248168 | 0.87 | GPR84 (0.68) | GPR84PDE4AKDM4EALDH1A1MAPK1 | |
| SCHEMBL7248095 | 0.85 | GPR84 (0.69) | GPR84PDE4AKDM4EALDH1A1MAPK1 | |
| SCHEMBL7251105 | 0.84 | GPR84 (0.65) | GPR84PDE4AKDM4EALDH1A1MAPK1 | |
| SCHEMBL7245839 | 0.84 | GPR84 (0.64) | GPR84PDE4AKDM4EALDH1A1MAPK1 | |
| SCHEMBL7247287 | 0.84 | KDM4E (0.71) | GPR84PDE4AKDM4EALDH1A1MAPK1 | |
| SCHEMBL7252167 | 0.82 | GPR84 (0.63) | GPR84PDE4AKDM4EALDH1A1MAPK1 | |
| SCHEMBL7247513 | 0.81 | GPR84 (0.65) | GPR84PDE4AKDM4EALDH1A1MAPK1 | |
| SCHEMBL7247620 | 0.81 | GPR84 (0.61) | GPR84PDE4AKDM4EALDH1A1MAPK1 | |
| SCHEMBL10907555 | 0.81 | GPR84 (0.78) | GPR84PDE4AKDM4EALDH1A1MAPK1 | |
| SCHEMBL7247192 | 0.81 | GPR84 (0.61) | GPR84PDE4AKDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030119813-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | VERNALIS LIMITED (GB) | 2003-06-26 | — | — | US | claimed |
| US-20030119813-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | VERNALIS LIMITED (GB) | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119813-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | CCR6, CXCR6, HRH1 | GPR84 812/4885PDE4A 584/4885KDM4E 3283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.