Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | HPGD | P15428 | 5/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | GAA | P10253 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.64 |
| ▸ | PDE4A | P27815 | 5/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | HK1 | P19367 | 1/20 | 0.57 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7251105 | 0.88 | GPR84 (0.65) | KDM4EALDH1A1HPGDMAPK1MAPT | |
| SCHEMBL7252167 | 0.85 | GPR84 (0.63) | KDM4EALDH1A1HPGDMAPK1MAPT | |
| SCHEMBL7253214 | 0.85 | KDM4E (0.60) | KDM4EALDH1A1HPGDMAPK1MAPT | |
| SCHEMBL7248968 | 0.84 | GPR84 (0.79) | KDM4EALDH1A1HPGDMAPK1MAPT | |
| SCHEMBL7247192 | 0.83 | GPR84 (0.61) | KDM4EALDH1A1HPGDMAPK1MAPT | |
| SCHEMBL7248168 | 0.82 | GPR84 (0.68) | KDM4EALDH1A1HPGDMAPK1MAPT | |
| SCHEMBL7248804 | 0.81 | GPR84 (0.59) | KDM4EALDH1A1HPGDMAPK1MAPT | |
| SCHEMBL5117237 | 0.81 | ALDH1A1 (0.67) | KDM4EALDH1A1HPGDMAPK1MAPT | |
| SCHEMBL30640051 | 0.81 | ALDH1A1 (0.67) | KDM4EALDH1A1HPGDMAPK1MAPT | |
| SCHEMBL7248095 | 0.80 | GPR84 (0.69) | KDM4EALDH1A1HPGDMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030119813-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | VERNALIS LIMITED (GB) | 2003-06-26 | — | — | US | claimed |
| US-20030119813-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | VERNALIS LIMITED (GB) | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119813-A1 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one | CCR6, CXCR6, HRH1 | KDM4E 3283/4885ALDH1A1 666/4885HPGD 2392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.