Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3225436 | 0.87 | MAP2K1 (0.62) | MAP2K1SRC | |
| SCHEMBL7696154 | 0.82 | TGFBR1 (0.46) | APPALKMAP4K4TGFBR1 | |
| SCHEMBL7247799 | 0.80 | RET (0.47) | MAP2K1RETAPPALKHRH3 | |
| SCHEMBL7249493 | 0.78 | SRC (0.59) | MAP2K1RETSRC | |
| SCHEMBL3216659 | 0.77 | MAP2K1 (0.62) | MAP2K1SRC | |
| SCHEMBL3231242 | 0.74 | MAP2K1 (0.61) | MAP2K1SRC | |
| SCHEMBL4557789 | 0.74 | MAP2K1 (0.73) | MAP2K1SRC | |
| SCHEMBL5259570 | 0.71 | MAP2K1 (0.47) | MAP2K1SRC | |
| SCHEMBL3228480 | 0.71 | MAP2K1 (0.55) | MAP2K1SRC | |
| SCHEMBL3224747 | 0.70 | SRC (0.47) | MAP2K1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521618-B2 | Antineoplastic agents, agents for treatment of osteoporosis and polycystic kidney disease | WYETH | 2003-02-18 | — | — | US | disclosed |