Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CCR1 | P32246 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5059118 | 0.84 | KDM4E (0.63) | KDM4ESMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL5055862 | 0.83 | ABCB11 (0.61) | KDM4ESMN1; SMN2ALDH1A1CCR1LMNA | |
| SCHEMBL5059394 | 0.82 | LMNA (0.58) | KDM4ESMN1; SMN2ALDH1A1CCR1LMNA | |
| SCHEMBL5059450 | 0.81 | MEN1 (0.67) | KDM4ESMN1; SMN2ALDH1A1CCR1LMNA | |
| SCHEMBL5061304 | 0.80 | CCR1 (0.55) | KDM4ESMN1; SMN2ALDH1A1CCR1LMNA | |
| SCHEMBL5061113 | 0.80 | CYP3A4 (0.59) | KDM4ESMN1; SMN2ALDH1A1CCR1LMNA | |
| SCHEMBL5059169 | 0.80 | KDM4E (0.63) | KDM4ESMN1; SMN2ALDH1A1CCR1LMNA | |
| SCHEMBL5055500 | 0.79 | LMNA (0.58) | KDM4ESMN1; SMN2ALDH1A1CCR1LMNA | |
| SCHEMBL5064456 | 0.79 | LMNA (0.58) | KDM4ESMN1; SMN2ALDH1A1CCR1LMNA | |
| SCHEMBL5060577 | 0.79 | LMNA (0.58) | KDM4ESMN1; SMN2ALDH1A1CCR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030139425-A1 | Piperazine derivatives and their use as anti-inflammatory agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139425-A1 | Piperazine derivatives and their use as anti-inflammatory agents | IL5, PTGES2, PTGES | KDM4E 1780/4885SMN1; SMN2 4729/4885ALDH1A1 465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.