Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7249246 | 0.89 | RXFP1 (0.50) | RXFP1MAPTNPSR1PKMMEN1 | |
| SCHEMBL7242713 | 0.88 | RXFP1 (0.46) | RXFP1MAPTNPSR1PKMPOLB | |
| SCHEMBL7247667 | 0.88 | RXFP1 (0.48) | RXFP1MAPTNPSR1PKMMEN1 | |
| SCHEMBL7248937 | 0.87 | MAPT (0.54) | RXFP1MAPTNPSR1PKMMEN1 | |
| SCHEMBL7243166 | 0.85 | RXFP1 (0.48) | RXFP1MAPTNPSR1PKMMEN1 | |
| SCHEMBL7249312 | 0.83 | MAPT (0.49) | RXFP1MAPTNPSR1PKMMEN1 | |
| SCHEMBL7243924 | 0.82 | MAPT (0.53) | RXFP1MAPTNPSR1PKMMEN1 | |
| SCHEMBL7242624 | 0.80 | MAPT (0.65) | RXFP1MAPTNPSR1PKMMEN1 | |
| SCHEMBL7241756 | 0.80 | MAPT (0.51) | RXFP1MAPTNPSR1PKMMEN1 | |
| SCHEMBL7247694 | 0.79 | MAPT (0.53) | RXFP1MAPTNPSR1PKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030045532-A1 | Triazolo-pyrimidine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-03-06 | — | — | US | claimed |
| US-20030045532-A1 | Triazolo-pyrimidine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045532-A1 | Triazolo-pyrimidine derivatives as ligands for gaba receptors | GABRA3, GABRA2, GABRA4 | RXFP1 1388/4885MAPT 1447/4885NPSR1 95/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.