Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3285768 | 0.78 | CHEK1 (0.42) | — | |
| SCHEMBL7253221 | 0.78 | ALDH1A1 (0.34) | HSP90AB1KCNH2 | |
| SCHEMBL7244574 | 0.77 | POLB (0.35) | HSP90AB1KCNH2 | |
| SCHEMBL13005543 | 0.71 | CHEK1 (0.40) | — | |
| SCHEMBL31618054 | 0.71 | CHEK1 (0.40) | — | |
| SCHEMBL1900144 | 0.69 | HSP90AB1 (0.42) | HSP90AB1KCNH2 | |
| SCHEMBL29589353 | 0.67 | CHEK1 (0.49) | HSP90AB1KCNH2 | |
| SCHEMBL14421840 | 0.67 | HSP90AB1 (0.38) | HSP90AB1KCNH2 | |
| SCHEMBL17390198 | 0.65 | MEN1 (0.35) | — | |
| SCHEMBL3224749 | 0.65 | CHEK1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6600028-B1 | Tricyclic compound for use as viricide | AMERSHAM PHARMACIA BIOTECH UK LIMITED (GB) | 2003-07-29 | — | — | US | disclosed |
| EP-0973788-A1 | TRICYCLIC BASE ANALOGUES | Amersham Pharmacia Biotech UK Limited (GB) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998043991-A1 | TRICYCLIC BASE ANALOGUES | AMERSHAM PHARMACIA BIOTECH UK LIMITED (GB) | 1998-10-08 | — | — | WO | disclosed |