Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7244574 | 0.81 | POLB (0.35) | THRBHSP90AB1KCNH2PPARG | |
| SCHEMBL7249503 | 0.78 | HSP90AB1 (0.32) | HSP90AB1KCNH2 | |
| SCHEMBL1900144 | 0.70 | HSP90AB1 (0.42) | HSP90AB1KCNH2PPARG | |
| SCHEMBL14421840 | 0.68 | HSP90AB1 (0.38) | HSP90AB1KCNH2 | |
| SCHEMBL20067795 | 0.63 | HSP90AB1 (0.33) | HSP90AB1 | |
| SCHEMBL27096442 | 0.63 | LMNA (0.34) | ALDH1A1TP53ADORA3ADORA2APPARG | |
| SCHEMBL28191390 | 0.63 | MTNR1A (0.52) | ALDH1A1 | |
| SCHEMBL28805816 | 0.61 | HTR2A (0.58) | ALDH1A1THRBADORA2AL3MBTL1 | |
| SCHEMBL16765811 | 0.59 | CHEK1 (0.49) | — | |
| SCHEMBL29782982 | 0.59 | LMNA (0.64) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6600028-B1 | Tricyclic compound for use as viricide | AMERSHAM PHARMACIA BIOTECH UK LIMITED (GB) | 2003-07-29 | — | — | US | disclosed |
| EP-0973788-A1 | TRICYCLIC BASE ANALOGUES | Amersham Pharmacia Biotech UK Limited (GB) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998043991-A1 | TRICYCLIC BASE ANALOGUES | AMERSHAM PHARMACIA BIOTECH UK LIMITED (GB) | 1998-10-08 | — | — | WO | disclosed |