Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 14/20 | 0.46 |
| ▸ | EDNRB | P24530 | 9/20 | 0.46 |
| ▸ | DHPS | P49366 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7248679 | 0.91 | EDNRA (0.57) | EDNRAEDNRBDHPS | |
| SCHEMBL6972015 | 0.84 | DHPS (0.53) | EDNRAEDNRBDHPS | |
| SCHEMBL6969386 | 0.84 | EDNRA (0.53) | EDNRAEDNRBDHPS | |
| SCHEMBL5035301 | 0.84 | EDNRA (0.66) | EDNRAEDNRB | |
| SCHEMBL6957003 | 0.83 | EDNRA (0.47) | EDNRAEDNRBDHPS | |
| SCHEMBL6972208 | 0.83 | DHPS (0.53) | EDNRAEDNRBDHPS | |
| SCHEMBL6972565 | 0.81 | EDNRA (0.47) | EDNRAEDNRBDHPS | |
| SCHEMBL5032747 | 0.81 | EDNRA (0.67) | EDNRAEDNRB | |
| SCHEMBL6961198 | 0.80 | EDNRA (0.47) | EDNRAEDNRBDHPS | |
| SCHEMBL6959001 | 0.80 | EDNRA (0.62) | EDNRAEDNRBDHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521631-B2 | N-(6-methoxy-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4 -yl)) 5-isopropyl-pyridine-2-sulfonamide; treatment of disorders which are associated with abnormal vascular tone and endothelial dysfunction. | HOFFMANN-LA ROCHE INC. | 2003-02-18 | — | — | US | disclosed |