Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7248834 | 1.00 | OPRM1 (0.37) | OPRM1OPRD1OPRK1DRD2DRD1 | |
| SCHEMBL9749669 | 0.72 | ESR1 (0.43) | OPRM1OPRD1OPRK1BRD4CREBBP | |
| SCHEMBL7079114 | 0.72 | PPARG (0.51) | ESR1ESR2 | |
| SCHEMBL6791705 | 0.66 | PPARG (0.58) | — | |
| SCHEMBL10638891 | 0.65 | KDM4E (0.35) | BRD4ESR1ESR2 | |
| SCHEMBL7081949 | 0.64 | ESR2 (0.43) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL7081951 | 0.64 | ESR2 (0.43) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL7248833 | 0.64 | ESR2 (0.43) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL6797538 | 0.63 | PPARA (0.49) | — | |
| SCHEMBL5543458 | 0.62 | SHBG (0.44) | DRD2DRD1DRD4DRD5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645997-B2 | Agonists of peroxisome proliferator activated receptor (PPAR) alpha and/or gamma | MERCK & CO., INC. | 2003-11-11 | — | — | US | disclosed |