Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30187807 | 0.83 | DAPK3 (0.33) | MAPTJAK2 | |
| SCHEMBL29886346 | 0.76 | — | — | |
| SCHEMBL39899 | 0.73 | MAPT (0.44) | NR1H2MAPTESR2KDM4ETHRB | |
| SCHEMBL31535874 | 0.73 | NR1H2 (0.53) | NR1H2NAMPTMAPTESR2ACACB | |
| SCHEMBL8223979 | 0.72 | NR1H2 (0.55) | NR1H2NAMPTMAPTESR2ACACB | |
| SCHEMBL1018783 | 0.72 | NR1H2 (0.58) | NR1H2NAMPTHPGDSMAPTESR2 | |
| SCHEMBL30793545 | 0.70 | NR1H2 (0.56) | NR1H2NAMPTMAPTESR2ACACB | |
| SCHEMBL24209513 | 0.70 | HPGDS (0.47) | NR1H2IDO1TDO2HPGDSMAPT | |
| SCHEMBL26703719 | 0.69 | NR1H2 (0.52) | NR1H2NAMPTMAPTESR2DDB1 | |
| SCHEMBL24209455 | 0.69 | NR1H2 (0.45) | NR1H2NAMPTIDO1TDO2HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609097-A1 | PYRIDYL-AMINE FUSED AZADECALIN MODULATORS | Corcept Therapeutics, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027702-A1 | PYRIDYL-AMINE FUSED AZADECALIN MODULATORS | CORCEPT THERAPEUTICS, INC. (US) | 2012-03-01 | — | — | WO | disclosed |