Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.67 |
| ▸ | MGLL | Q99685 | 8/20 | 0.58 |
| ▸ | GABRD | O14764 | 1/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.52 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358286 | 0.90 | SIGMAR1 (0.76) | SIGMAR1GABRDGABRA1GABRB1GABRA5 | |
| SCHEMBL3584183 | 0.85 | SIGMAR1 (0.69) | SIGMAR1GABRDGABRA1GABRB1GABRA5 | |
| SCHEMBL2644377 | 0.84 | HPGD (0.67) | MGLLALDH1A1TP53 | |
| SCHEMBL15605882 | 0.84 | SMN1; SMN2 (0.65) | MGLLALDH1A1TP53 | |
| SCHEMBL20267190 | 0.83 | SIGMAR1 (0.72) | SIGMAR1GABRDGABRA1GABRB1GABRA5 | |
| SCHEMBL4053730 | 0.83 | HPGD (0.68) | MGLLALDH1A1 | |
| SCHEMBL4053727 | 0.83 | HPGD (0.68) | MGLLALDH1A1 | |
| SCHEMBL30957287 | 0.83 | HPGD (0.68) | MGLLALDH1A1 | |
| SCHEMBL2336862 | 0.82 | SMN1; SMN2 (0.71) | SIGMAR1ALDH1A1 | |
| SCHEMBL14107680 | 0.82 | SIGMAR1 (0.65) | SIGMAR1MGLLGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102898377-A | Novel phthalazinone derivatives and uses thereof | NANJING SANHOME PHARMACEUTICAL CO LTD | 2013-01-30 | — | — | CN | disclosed |
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |