Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 5/20 | 0.63 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | GABRD | O14764 | 1/20 | 0.54 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.54 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.54 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358286 | 0.95 | SIGMAR1 (0.76) | SIGMAR1HPGDL3MBTL3L3MBTL1LMNA | |
| SCHEMBL10720984 | 0.89 | HPGD (0.76) | HPGDL3MBTL3L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL20267190 | 0.88 | SIGMAR1 (0.72) | SIGMAR1L3MBTL3L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL7127339 | 0.87 | HPGD (0.77) | HPGDL3MBTL3L3MBTL1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL30444118 | 0.87 | SIGMAR1 (0.70) | SIGMAR1HPGDL3MBTL3L3MBTL1SMN1; SMN2 | |
| SCHEMBL4709504 | 0.87 | SIGMAR1 (0.65) | SIGMAR1HPGDLMNAALDH1A1HTT | |
| SCHEMBL3583338 | 0.85 | HPGD (0.73) | SIGMAR1HPGDL3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL7252122 | 0.85 | SIGMAR1 (0.67) | SIGMAR1ALDH1A1GABRDGABRA1GABRB1 | |
| SCHEMBL14107680 | 0.83 | SIGMAR1 (0.65) | SIGMAR1HPGDALDH1A1GABRDGABRA1 | |
| SCHEMBL8355984 | 0.83 | SIGMAR1 (0.65) | SIGMAR1ALDH1A1GABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075953-A1 | SUBSTITUTED PIPERAZINES, (1,4) DIAZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075953-A1 | SUBSTITUTED PIPERAZINES, (1,4) DIAZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS | HRH3, HRH4, HRH2 | SIGMAR1 487/4885HPGD 368/4885L3MBTL3 4312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.