Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29612197 | 1.00 | AHR (0.44) | AHRPDK2DRD2DRD4DRD3 | |
| SCHEMBL2235526 | 0.84 | NPC1 (0.46) | HTR1AOPRK1 | |
| SCHEMBL30609062 | 0.84 | DRD2 (0.46) | AHRPDK2DRD2DRD4DRD3 | |
| SCHEMBL13930334 | 0.84 | DRD2 (0.46) | AHRPDK2DRD2DRD4DRD3 | |
| SCHEMBL4041542 | 0.75 | AHR (0.45) | AHRPDK2CCNB2CDK1CCNB1 | |
| SCHEMBL31364658 | 0.72 | SMYD3 (0.43) | AHRPDK2DRD2HTR1AKCNH2 | |
| SCHEMBL4790991 | 0.72 | AHR (0.39) | AHRPDK2DRD2DRD4DRD3 | |
| SCHEMBL836954 | 0.72 | AHR (0.48) | AHRPDK2DRD2DRD4DRD3 | |
| SCHEMBL3340538 | 0.72 | AHR (0.48) | AHRPDK2DRD2DRD4DRD3 | |
| SCHEMBL12326143 | 0.72 | AHR (0.48) | AHRPDK2DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117567351-A | Preparation method of 4- (2-bromoethyl) -1, 3-dihydro-2H-indol-2-one | 常州锐博生物科技有限公司 | 2024-02-20 | — | — | CN | disclosed |
| WO-2023201012-A1 | IKZF2 DEGRADERS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2023-10-19 | — | — | WO | disclosed |
| CN-112745256-B | Preparation method of 4- (2-bromoethyl) -1, 3-dihydro-2H-indol-2-one | 常州锐博生物科技有限公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-112745256-A | Preparation method of 4- (2-bromoethyl) -1, 3-dihydro-2H-indol-2-one | 常州锐博生物科技有限公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-105385011-B | A kind of TPV compositions and automobile collision preventing billot | 嘉兴市博尔塑胶有限公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-105385011-A | TPV composition and automobile anti-collision strip | Jiaxing boer plastic co ltd | 2016-03-09 | — | — | CN | disclosed |
| US-9238025-B2 | Transdermal preparation comprising a ropinirole derivative | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2016-01-19 | — | — | US | disclosed |
| US-9238025-B2 | Transdermal preparation comprising a ropinirole derivative | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2016-01-19 | — | — | US | disclosed |
| US-9238025-B2 | Transdermal preparation comprising a ropinirole derivative | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2016-01-19 | — | — | US | disclosed |
| EP-2438917-B1 | TRANSDERMAL PREPARATION | HISAMITSU PHARMACEUTICAL CO (JP) | 2014-09-03 | — | — | EP | disclosed |
| US-20120052113-A1 | TRANSDERMAL PREPARATION | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2012-03-01 | — | — | US | disclosed |
| US-20120052113-A1 | TRANSDERMAL PREPARATION | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2012-03-01 | — | — | US | disclosed |
| US-20120052113-A1 | TRANSDERMAL PREPARATION | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2012-03-01 | — | — | US | disclosed |
| US-7378439-B2 | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride | USV, LTD. (IN) | 2008-05-27 | — | — | US | disclosed |
| US-7378439-B2 | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride | USV, LTD. (IN) | 2008-05-27 | — | — | US | disclosed |
| EP-0300614-B1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED INDOLINONE DERIVATIVES | SMITH KLINE FRENCH LAB (GB) | 1993-08-25 | — | — | EP | disclosed |
| CN-1019296-B | IMPROVED PROCESS FOR SUBSTITUTED INDOLINONE DERIVATIVES | SMITH KLINE FRENCH LAB (GB) | 1992-12-02 | — | — | CN | disclosed |
| US-4997954-A | Process for preparing substituted isoindolinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0300614-A1 | Process for the preparation of substituted indolinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-01-25 | — | — | EP | disclosed |
| CN-1030076-A | The improved preparation of the indolinone derivative that replaces | SMITH KLINE FRENCH LAB (GB) | 1989-01-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120052113-A1 | TRANSDERMAL PREPARATION | HTR3D, HTR5A, HTR1E | AHR 1888/4885PDK2 1998/4885DRD2 959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.