SCHEMBL7253229

SCHEMBL7253229

Cn1nc(C(F)(F)F)cc1-c1cc(C#N)cc(OCc2ccccc2)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 4/20 0.42
CTSL P07711 1/20 0.39
PKM P14618 1/20 0.38
ALDH1A1 P00352 2/20 0.37
MAOB P27338 1/20 0.37
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
KMT2A Q03164 1/20 0.37
GABRG2 P18507 1/20 0.37
GABRB3 P28472 1/20 0.37
GABRA5 P31644 1/20 0.37
GABRA3 P34903 1/20 0.37
PDPK1 O15530 1/20 0.36
MMP13 P45452 1/20 0.36
ALOX5 P09917 1/20 0.36
PTGS1 P23219 1/20 0.36
PTGS2 P35354 1/20 0.36
KDM4C Q9H3R0 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7245294 0.78 SCN9A (0.40) NPC1RAB9AKMT2AALOX5PTGS1
SCHEMBL8479783 0.77 MMP13 (0.39) GRM5ALDH1A1KDM4EMEN1KMT2A
SCHEMBL8481120 0.73 GRM5 (0.40) GRM5ALDH1A1KDM4EKMT2ASCN9A
SCHEMBL5781569 0.71 ADORA2A (0.47) PKMALDH1A1MEN1NPC1RAB9A
SCHEMBL8475741 0.69 ADORA2A (0.46) ALDH1A1KDM4EKMT2AALOX5PTGS1
SCHEMBL8773244 0.69 GRM5 (0.47) GRM5ALDH1A1MAOBKDM4EGABRG2
SCHEMBL8480151 0.69 ADORA2A (0.37) ALDH1A1MAOBKDM4EKMT2AGABRG2
SCHEMBL8773165 0.69 GRM5 (0.78) GRM5MAOBMEN1KMT2AGABRG2
SCHEMBL14822776 0.68 PTGS2 (0.54) ALDH1A1KDM4ENPC1RAB9AKMT2A
SCHEMBL19319877 0.68 STIM1 (0.42) ALDH1A1MAOBMEN1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6528456-B2 Selectivity, desirable rate of degradation in soil BASF AKTIENGESELLSCHAFT (DE) 2003-03-04 US claimed