Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.80 |
| ▸ | MMP9 | P14780 | 12/20 | 0.80 |
| ▸ | MMP1 | P03956 | 9/20 | 0.80 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.76 |
| ▸ | MMP13 | P45452 | 2/20 | 0.57 |
| ▸ | MMP14 | P50281 | 2/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.57 |
| ▸ | MMP7 | P09237 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP15 | P51511 | 1/20 | 0.57 |
| ▸ | MMP16 | P51512 | 1/20 | 0.57 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629464 | 1.00 | MMP2 (0.80) | MMP2MMP9MMP1ADAM17MMP13 | |
| SCHEMBL6628418 | 0.89 | MMP9 (1.00) | MMP2MMP9MMP1ADAM17MMP13 | |
| SCHEMBL7247215 | 0.87 | MMP2 (0.71) | MMP2MMP9MMP1ADAM17MMP13 | |
| SCHEMBL6627898 | 0.86 | ADAM17 (1.00) | MMP2MMP9MMP1ADAM17MMP13 | |
| SCHEMBL6628726 | 0.86 | ADAM17 (0.83) | MMP2MMP9MMP1ADAM17MMP13 | |
| SCHEMBL6629466 | 0.85 | MMP9 (0.79) | MMP2MMP9MMP1ADAM17MMP13 | |
| SCHEMBL6628207 | 0.85 | MMP2 (0.79) | MMP2MMP9MMP1ADAM17MMP13 | |
| SCHEMBL6628071 | 0.84 | MMP2 (1.00) | MMP2MMP9MMP1ADAM17MMP13 | |
| SCHEMBL7243883 | 0.83 | ADAM17 (0.90) | MMP2MMP9MMP1ADAM17MMP13 | |
| SCHEMBL6626648 | 0.82 | MMP2 (1.00) | MMP2MMP9MMP1ADAM17MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610731-B2 | Antiinflammatory | BRISTOL-MYERS SQUIBB COMPANY | 2003-08-26 | — | — | US | disclosed |
| US-6403632-B1 | CYCLIC AMIDE DERIVATIVE | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2002-06-11 | — | — | US | disclosed |
| US-6057336-A | ANTIINFLAMMATORY AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-05-02 | — | — | US | disclosed |