Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | RORB | Q92753 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15577176 | 0.81 | BTK (0.46) | ADORA2AADORA1KDM4EMEN1ALDH1A1 | |
| SCHEMBL19078912 | 0.80 | MAPT (0.42) | ADORA2AADORA1JUNNFKB1NFKB2 | |
| SCHEMBL31334102 | 0.80 | MAPT (0.42) | ADORA2AADORA1JUNNFKB1NFKB2 | |
| SCHEMBL13120752 | 0.79 | BIRC5 (0.42) | HRH1HRH4MEN1ALDH1A1HPGD | |
| SCHEMBL31333468 | 0.78 | BTK (0.38) | ADORA1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL31333278 | 0.78 | JUN (0.40) | JUNNFKB1NFKB2RELAMEN1 | |
| SCHEMBL3758203 | 0.77 | KDM4E (0.52) | ADORA2AADORA1JUNNFKB1NFKB2 | |
| SCHEMBL7216188 | 0.77 | ADORA2A (0.60) | ADORA2AADORA1TDP1SCN2AJUN | |
| SCHEMBL1467372 | 0.75 | ALDH1A1 (0.47) | JUNNFKB1NFKB2RELADYRK1A | |
| SCHEMBL15577238 | 0.75 | CLK4 (0.46) | ADORA2AADORA1IDO1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003030909-A1 | 2- AND 4-AMINOPYRIMIDINES N-SUBSTTITUDED BY A BICYCLIC RING FOR USE AS KINASE INHIBITORS IN THE TREATMENT OF CANCER | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-17 | — | — | WO | disclosed |