Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6407211 | 0.92 | PDE5A (0.34) | KCNH2DRD2DRD3DYRK1ACHRNA7 | |
| SCHEMBL7254113 | 0.67 | PDE5A (0.59) | — | |
| SCHEMBL7254126 | 0.64 | PDE5A (0.43) | — | |
| SCHEMBL15965710 | 0.63 | GPR84 (0.40) | KCNH2DRD2DRD3MAOAMAOB | |
| SCHEMBL16452338 | 0.62 | MKNK1 (0.34) | KCNH2DRD2DRD3MAOAMAOB | |
| SCHEMBL15964334 | 0.61 | L3MBTL1 (0.46) | DYRK1A | |
| SCHEMBL20426812 | 0.60 | CHRNA7 (0.35) | KCNH2MAOADYRK1ACHRNA7 | |
| SCHEMBL20426625 | 0.60 | PTPN1 (0.38) | KCNH2MAOADYRK1ACHRNA7 | |
| SCHEMBL20426784 | 0.59 | KDM4E (0.37) | MAOAMAOB | |
| SCHEMBL19849125 | 0.59 | CHEK2 (0.34) | MAOAMAOBDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6635638-B2 | Treatment of sexual dysfunction, cardiovascular system disorders | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-10-21 | — | — | US | disclosed |